Differential effects of glyphosate and roundup on human placental cells and aromatase.
作者： Sophie Richard , Safa Moslemi , Herbert Sipahutar , Nora Benachour , Gilles-Eric Seralini
DOI: 10.1289/EHP.7728
关键词:
摘要: Roundup is a glyphosate-based herbicide used worldwide, including on most genetically modified plants that have been designed to tolerate it. Its residues may thus enter the food chain, and glyphosate found as contaminant in rivers. Some agricultural workers using pregnancy problems, but its mechanism of action mammals questioned. Here we show toxic human placental JEG3 cells within 18 hr with concentrations lower than those use, this effect increases concentration time or presence adjuvants. Surprisingly, always more active ingredient. We tested effects at nontoxic aromatase, enzyme responsible for estrogen synthesis. The disrupts aromatase activity mRNA levels interacts site purified enzyme, are facilitated by formulation microsomes cell culture. conclude endocrine Roundup, not just glyphosate, can be observed mammals. suggest adjuvants enhances bioavailability and/or bioaccumulation.
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