HopZ4 from Pseudomonas syringae, a Member of the HopZ Type III Effector Family from the YopJ Superfamily, Inhibits the Proteasome in Plants

摘要: The YopJ family of type III effector proteins (T3E) is one the largest and most widely distributed families proteins, whose members are highly diversified in virulence functions. In present study, HopZ4, a member T3E from cucumber pathogen Pseudomonas syringae pv. lachrymans described. HopZ4 shares high sequence similarity with Xanthomonas XopJ, functional analysis suggests conserved function between these two T3E. As has previously been shown for interacts proteasomal subunit RPT6 yeast planta to inhibit proteasome activity during infection. inhibitory effect on dependent localization plasma membrane as well an intact catalytic triad protein. Furthermore, able complement loss XopJ spp., it prevents precocious host cell death compatible Xanthomonas-pepper interaction. data presented here suggest that different bacterial species employ inhibition strategy by making use proteins.