Degradation behavior of poly(epsilon-caprolactone)-b-poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles in aqueous solution.

摘要: Poly(e-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone) triblock copolymers were synthesized by the ring-opening polymerization of e-caprolactone in presence hydroxyl-terminated poly(ethylene glycol) with different molecular weights, using stannous octoate catalyst. Micelles prepared precipitation method these exhibit a core−shell structure. The degradation behaviors micelles aqueous solution investigated FT-IR, 1H NMR, GPC, DLS, TEM, and AFM. It was found that behavior quite from bulk materials. size increased initial stages decreased gradually when period extended. caprolactone/ethylene oxide (CL/EO) ratio measured NMR also shows an increase at stage decrease later stages. morphology became more irregular durin...