Can radiation research impact the estimation of risk?

摘要: AbstractPurpose: This review is a contribution to the memory of Dr William (Bill) Morgan and highlights an area research deliberation that he considered extremely important in support setting protective radiation dose limits. Biological has generally played minor role estimation adverse health outcomes following exposure low doses rates radiation. The reliance been on available, quite extensive data base epidemiology studies. major concern such studies are for moderate high requiring risk extrapolation methodologies estimating effects. There significant uncertainties associated with this approach. will discuss how biology can potentially reduce uncertainty through use key events/adverse outcome pathways approach identify bioindicators cancer non-cancer effects as parameters biologically-based dose-response (BBDR) models. Such models woul...