Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice
作者： W. F. Heidenreich , M. Rosemann
DOI: 10.1007/S00411-012-0409-X
关键词:
摘要: We explore the potential for biologically based two-stage clonal expansion model to make statements about influence of genetic factors on steps in model. find evidence that different susceptibility BALB/C and CBA/Ca mice bone cancer after 227Thorium injection may be mostly due promotional responses radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed specific contribution two individual loci carcinogenic process. This analysis suggests high- or low-risk alleles are acting promotion background parameters, but not radiation-induced initiation. Taken together with comparison this hints at possibility candidates modifying promotion.
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