SLUG Directs the Precursor State of Human Brain Tumor Stem Cells

摘要: In glioblastoma (GBM), brain tumor stem cells (BTSCs) encompass heterogenous populations of multipotent, self-renewing, and tumorigenic cells, which have been proposed to be at the root therapeutic resistance recurrence. While functional significance BTSC heterogeneity remains fully determined, we previously distinguished relatively quiescent stem-like precursor state from more aggressive progenitor-like state. present study, hypothesized that BTSCs arise precursors through a mesenchymal transition drive post-treatment We first demonstrate display transcriptomic profile. Moreover, show both GBMs are characterized by over-activated STAT3/EMT pathways SLUG is primary epithelial (EMT) transcription factor directly regulated STAT3 in BTSCs. overexpression enhances invasiveness, promotes inflammation, shortens survival. Importantly, line tumorigenesis. Finally, report recurrence associated with SLUG-induced transcriptional changes GBM patient samples. Collectively, our findings STAT3-driven transition, mediated SLUG, may prime initiate Targeting STAT3/SLUG pathway maintain state, delaying improving survival GBM.