Sugammadex: a novel neuromuscular blocker binding agent

作者: Aaron M Fields , Nalini Vadivelu

DOI: 10.1097/ACO.0B013E32814B1612

关键词:

摘要: Purpose of reviewSugammadex is a novel drug that binds selected neuromuscular blocking drugs and prevents them from acting at the junction. Due to its rapid onset relative lack side effects, this promises change method anesthesia delivery. This review summarizes t

参考文章(16)
Thomas M. Hemmerling, Nhien Le, Brief review: Neuromuscular monitoring: an update for the clinician. Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 54, pp. 58- 72 ,(2007) , 10.1007/BF03021901
Hans D. de Boer, Jan van Egmond, Francien van de Pol, Anton Bom, Leo H. D. J. Booij, Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys. Anesthesiology. ,vol. 104, pp. 718- 723 ,(2006) , 10.1097/00000542-200604000-00016
P. Schultz, M. Ibsen, D. Østergaard, L. T. Skovgaard, Onset and duration of action of rocuronium--from tracheal intubation, through intense block to complete recovery. Acta Anaesthesiologica Scandinavica. ,vol. 45, pp. 612- 617 ,(2001) , 10.1034/J.1399-6576.2001.045005612.X
Julia M. Adam, D. Jonathan Bennett, Anton Bom, John K. Clark, Helen Feilden, Edward J. Hutchinson, Ronald Palin, Alan Prosser, David C. Rees, Georgina M. Rosair, Donald Stevenson, Gary J. Tarver, Ming-Qiang Zhang, Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. Journal of Medicinal Chemistry. ,vol. 45, pp. 1806- 1816 ,(2002) , 10.1021/JM011107F
Gabriella Bettelli, Which muscle relaxants should be used in day surgery and when. Current Opinion in Anesthesiology. ,vol. 19, pp. 600- 605 ,(2006) , 10.1097/ACO.0B013E32801062EB
Koen Suy, Karl Morias, Guy Cammu, Pol Hans, Wilbert G. F. van Duijnhoven, Marten Heeringa, Ignace Demeyer, Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent. Anesthesiology. ,vol. 106, pp. 283- 288 ,(2007) , 10.1097/00000542-200702000-00016
Francois Gijsenbergh, Steven Ramael, Natalie Houwing, Thijs van Iersel, First Human Exposure of Org 25969, a Novel Agent to Reverse the Action of Rocuronium Bromide Anesthesiology. ,vol. 103, pp. 695- 703 ,(2005) , 10.1097/00000542-200510000-00007