Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones

摘要: γ-Butenolides, γ-butyrolactones, and derivatives, especially in enantiomerically pure form, constitute the structural core of numerous natural products which display an impressive range biological activities are important for development novel physiological therapeutic agents. Furthermore, optically active γ-butenolides γ-butyrolactones serve also as a prominent class chiral building blocks synthesis diverse compounds complex molecules. Taking into account varying activity profiles wide-ranging diversity γ-butenolide or γ-butyrolactone structure, asymmetric synthetic strategies assembling such challenging scaffolds has attracted major attention from chemists past decade. This review offers overview different enantioselective employ catalytic amounts metal complexes organocatalysts, wit...