An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress
DOI: 10.1016/J.MCN.2012.07.005
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摘要: Abstract The activity of mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is severely reduced in human pathologies where oxidative stress traditionally thought to play an important role, such as familial and sporadic forms Alzheimer's disease other age-related neurodegenerative diseases. This minireview focused on substantial data that were accumulated over the last 2 decades support concept KGDHC can be a primary target at same time key contributor it by producing reactive oxygen species. article part Special Issue entitled ‘Mitochondrial function dysfunction neurodegeneration’.
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Edith Maas, Hans Bisswanger, Localization of the α-oxoacid dehydrogenase multienzyme complexes within the mitochondrion FEBS Letters. ,vol. 277, pp. 189- 190 ,(1990) , 10.1016/0014-5793(90)80840-F
Vera G. Grivennikova, Gary Cecchini, Andrei D. Vinogradov, Ammonium-dependent hydrogen peroxide production by mitochondria FEBS Letters. ,vol. 582, pp. 2719- 2724 ,(2008) , 10.1016/J.FEBSLET.2008.06.054
Elisa Cabiscol, Eva Piulats, Pedro Echave, Enrique Herrero, Joaquim Ros, Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae Journal of Biological Chemistry. ,vol. 275, pp. 27393- 27398 ,(2000) , 10.1074/JBC.M003140200
Kenneth M. Humphries, Young Yoo, Luke I. Szweda, Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal† Biochemistry. ,vol. 37, pp. 552- 557 ,(1998) , 10.1021/BI971958I
Frank Mastrogiacomo, Catherine Bergeron, Stephen J. Kish, Brain α‐Ketoglutarate Dehydrotenase Complex Activity in Alzheimer's Disease Journal of Neurochemistry. ,vol. 61, pp. 2007- 2014 ,(1993) , 10.1111/J.1471-4159.1993.TB07436.X
Victoria Bunik, Hartmut Follmann, Hans Bisswanger, Activation of mitochondrial 2-oxoacid dehydrogenases by thioredoxin. Biological Chemistry. ,vol. 378, pp. 1125- 1130 ,(1997) , 10.1515/BCHM.1997.378.10.1125
Terence Wagenknecht, Noreen Francis, David J. DeRosier, α-Ketoglutarate dehydrogenase complex may be heterogeneous in quaternary structure Journal of Molecular Biology. ,vol. 165, pp. 523- 539 ,(1983) , 10.1016/S0022-2836(83)80217-4
G.E. Gibson, H. Zhang, K.-F.R. Sheu, L.C.H. Park, Differential alterations in antioxidant capacity in cells from Alzheimer patients. Biochimica et Biophysica Acta. ,vol. 1502, pp. 319- 329 ,(2000) , 10.1016/S0925-4439(00)00057-0
G. Zündorf, S. Kahlert, V.I. Bunik, G. Reiser, α-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ Neuroscience. ,vol. 158, pp. 610- 616 ,(2009) , 10.1016/J.NEUROSCIENCE.2008.10.015
G.E Gibson, A.E Kingsbury, H Xu, J.G Lindsay, S Daniel, O.J.F Foster, A.J Lees, J.P Blass, Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson’s disease Neurochemistry International. ,vol. 43, pp. 129- 135 ,(2003) , 10.1016/S0197-0186(02)00225-5