Ringtail in suckling Munich Wistar Fromter rats: a histopathologic study.

摘要: Ringtail is a pathologic condition of the tail rats and other rodents that traditionally attributed to low environmental humidity, although dietary deficiencies, genetic susceptibility, temperature, degree hydration animal also have been suggested as possible causes. To authors' knowledge, detailed histopathologic study may serve shed light on etiopathogenesis this disease has not yet published. We describe histologic findings ringtail observed in 12 suckling Munich Wistar Fromter (MWF) from two litters. Epidermal hyperplasia characterized by orthokeratotic parakeratotic hyperkeratosis acanthosis was all affected rats. Numerous often dilated vessels were present dermis tails appeared red/brown color at gross examination. In severe cases, vascular structures thrombotic accompanied dermal hemorrhages focal coagulative necrosis overlying epidermis. These suggest epidermal are main primary events development ringtail. clarify cause disease, future studies should be focused numerous factors can induce such changes.