Evidence for a B-cell origin of the proliferating cells

摘要: Hodgkin’s disease differs from the non-Hodgkin’s lymphomas by presence of reactive lymphocytes, histiocytes, plasma cells, fibroblasts and eosinophils in addition to abnormal so-called Reed-Sternberg cells their variants (Figure 1). Usually, constitute only a minor population, whereas there is majority small lymphocytes. During disease, general tendency an increase number decrease lymphocyte admixture. The have been demonstrated be monoclonal proliferations B- or T-lymphocytes, but neither cell origin nor has established with certainty.