A structured literature review to determine the use of the American Society for Therapeutic Radiology and Oncology consensus definition of biochemical failure

摘要: Abstract Objectives The American Society for Therapeutic Radiology and Oncology consensus definition (ACD) of biochemical failure after radiotherapy prostate cancer requires three consecutive prostate-specific antigen increases from a nadir value. members the Consensus Panel recognized that timing frequency determinations could affect comparability among different reports if this was used. For reason, recommended guidelines studies presented publication (publication [PGs]). present analysis examined extent to which ACD has been used in peer-reviewed published literature how frequently PGs have followed. Methods A structured review 10 relevant journals done. inclusion criteria required calendar year 1999 or 2000; treatment with external beam and/or brachytherapy previously untreated, nonmetastatic cancer; use antigen–defined disease-free endpoint. standardized checklist created completed by both authors. We independently reviewed each determine whether were Discrepancies between us resolved joint question achieve consensus. Results Fifty-seven articles met criteria. median number patients 302 (range 22 2222). followed 37 (64.9%) 57 articles. None all PGs. In five (8.7%), two vast majority (52 57, 91.3%) one none Panel. Conclusions thirds much less frequently. Consistent standards reporting not uniformly applied manuscripts.