Allergenicity of goat's milk in children with cow's milk allergy.

摘要: Abstract Background: Cow's milk allergy (CMA) is a common disease of infancy and childhood. An appropriate cow's (CM) substitute necessary for feeding babies with CMA. CM substitutes are soy formulas casein- or whey-based extensively hydrolyzed formulas. In several countries, including Italy, goat's (GM) available, some physicians recommend them Objective: We sought to investigate, in vitro vivo, the allergenicity GM 26 children proven IgE-mediated Methods: All underwent skin tests GM; detection specific serum IgE double-blind, placebo-controlled, oral food challenges (DBPCOFCs) fresh CM, GM, and, as placebo, formula (Isomil, Abbott, Italy). CAP inhibition immunoblotting assays were also carried out 1 4 positive RAST results both respectively. Results: had test responses all DBPCOFC 24 DBPCOFCs GM. tests, preincubation strongly inhibited either assays, completely extinguished reactivity whereas partially CM. Conclusions: These data indicate that not an A warning on lack safety CMA should be label prevent severe allergic reactions (J Allergy Clin Immunol 1999;103:1191-4.)