Polymer-Modified Nanoparticles as Targeted MR Imaging Agents

摘要: A novel surface modification technique was employed to produce a polymer-modified, positive contrast agent nanoparticle for targeted magnetic resonance imaging (MRI). range of both hydrophilic and hydrophobic homopolymers, along with multifunctional copolymers poly(N-(2-hydroxypropyl) methacrylamide)-co-poly(N-methacryloxysuccinimide)-co-poly(fluorescein O-methacrylate), were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. These polymers subsequently used modify the gadolinium (Gd) metal-organic framework (MOF) nanoparticles. The succinimide functionality copolymer utilized as scaffold attachment targeting ligands, H-glycine-arginine-glycine-aspartate-serine-NH2 peptide or antibody epidermal growth factor. Reduction trithiocarbonate RAFT polymer end groups thiolates provided means through vacant orbitals on Gd3+ ions at Gd MOF MRI confirmed that relaxivity rates these polymer-modified structures easily tuned by changes in size shape nanoparticles modifying molecular weight chemical structure attached In most cases, values significantly higher than unmodified clinically agents, Magnevist® MultiHance®. versatile, nanoscale scaffolds shown provide biocompatibility, cancer cell targeting, diagnostic fluorescence microscopy. This unique method simple yet versatile route producing an unprecedented degree flexibility construct, potentially allowing tunable loading capacities spatial agents while incorporating bimodal capabilities.