Modified Gadonanotubes as a promising novel

摘要: Background and purpose of the study: Carbon nanotubes (CNTs) are emerging drug imaging carrier systems which show significant versatility. One extraordinary characteristics CNTs as Magnetic Resonance Imaging (MRI) contrasting agent is extremely large proton relaxivities when loaded with gadolinium ion (Gdn )c lusters. Methods: In this study equated Gdn clusters were in sidewall defects oxidized multiwalled (MW) CNTs. The amount into MWCNTs was quantified by inductively coupled plasma (ICP) method. To improve water solubility biocompatibility system, complexes functionalized using diamineterminated oligomeric poly (ethylene glycol) via a thermal reaction Results: PEGylated @CNTs-PEG) freely soluble stable phosphate buffer saline having particle size about 200 nm. Transmission electron microscopy (TEM) images clearly showed formation MRI analysis that prepared solution represents 10% more signal intensity even half concentration Gd 3+ comparison commerciality available Magnevist W .I n addition hydrophilic layer PEG at surface could prepare stealth nanoparticles to escape RES. Conclusion: It shown @CNTs-PEG capable accumulate tumors through enhanced permeability retention effect. Moreover system has potential for early detection diseases or initial stages.