Fast and Accurate Rat Head Motion Tracking With Point Sources for Awake Brain PET
作者： Alan Miranda , Steven Staelens , Sigrid Stroobants , Jeroen Verhaeghe
关键词:
摘要: To avoid the confounding effects of anesthesia and immobilization stress in rat brain positron emission tomography (PET), motion tracking-based unrestrained awake imaging is being developed. In this paper, we propose a fast accurate headmotion tracking method based on small PET point sources. sources (3-4) attached to rat’s head are tracked image space using 15–32-ms time frames. Our source (PST) was validated manually moved microDerenzo phantom that simultaneously with an optical tracker (OT) for comparison. The PST further three [18F]FDG scans. Compared OT, PST-based correction at same frame rate (31.2 Hz) reduced reconstructed FWHM by 0.39–0.66 mm different tested rod sizes phantom. could be another 0.07–0.13 when increasing (66.7 Hz). Regional uptake corrected scan strongly correlated ( $p ) anesthetized reference all cases $0.94 ). proposed allowed excellent reproducible vivo experiments. addition, there no need specialized equipment or additional calibrations performed, practically imperceptible rat, ideally suitable bore scanners, where might challenging.
sci-hub.se 参考文章(30)
Victor Zhou, John Eisenhuth, Andre Kyme, Mahmood Akhtar, Roger Fulton, Steven Meikle, A Motion Adaptive Animal Chamber for PET Imaging of Freely Moving Animals IEEE Transactions on Nuclear Science. ,vol. 60, pp. 3423- 3431 ,(2013) , 10.1109/TNS.2013.2277857
Ignace Lemahieu, Bjorn De Sutter, Mark Christiaens, Erik Sundermann, Filip Jacobs, A Fast Algorithm to Calculate the Exact Radiological Path through a Pixel or Voxel Space computer and information technology. ,vol. 6, pp. 89- 94 ,(1998)
Matthew G Spangler-Bickell, Lin Zhou, Andre Z Kyme, Bart De Laat, Roger R Fulton, Johan Nuyts, Optimising rigid motion compensation for small animal brain PET imaging. Physics in Medicine and Biology. ,vol. 61, pp. 7074- 7091 ,(2016) , 10.1088/0031-9155/61/19/7074
Alan Miranda, Jeroen Verhaeghe, Joke Parthoens, Sigrid Stroobants, Steven Staelens, Motion uncertainty deblurring in motion corrected reconstruction for μPET brain imaging of awake rats nuclear science symposium and medical imaging conference. pp. 1- 4 ,(2014) , 10.1109/NSSMIC.2014.7431024
Carlos A. Martinez-Ortiz, 2D and 3D shape descriptors University of Exeter. ,(2010)
Davide Giavarina, Understanding Bland Altman analysis Biochemia Medica. ,vol. 25, pp. 141- 151 ,(2015) , 10.11613/BM.2015.015
Barbara J. Fueger, Johannes Czernin, Isabel Hildebrandt, Michael E. Phelps, Chris Tran, Benjamin S. Halpern, David Stout, Wolfgang A. Weber, Impact of Animal Handling on the Results of 18F-FDG PET Studies in Mice The Journal of Nuclear Medicine. ,vol. 47, pp. 999- 1006 ,(2006)
Jean Babaud, Andrew P. Witkin, Michel Baudin, Richard O. Duda, Uniqueness of the Gaussian Kernel for Scale-Space Filtering IEEE Transactions on Pattern Analysis and Machine Intelligence. ,vol. PAMI-8, pp. 26- 33 ,(1986) , 10.1109/TPAMI.1986.4767749
A Matsumura, Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: comparison between quantitative data obtained with microPET and ex vivo autoradiography. NeuroImage. ,vol. 20, pp. 2040- 2050 ,(2003) , 10.1016/J.NEUROIMAGE.2003.08.020
Mahmood Akhtar, Andre Kyme, Victor Zhou, Roger Fulton, Steven Meikle, An investigation of the challenges in reconstructing PET images of a freely moving animal Australasian Physical & Engineering Sciences in Medicine. ,vol. 36, pp. 405- 415 ,(2013) , 10.1007/S13246-013-0222-0