iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.
作者： Mari Sasaki , Shohei Shinozaki , Hironobu Morinaga , Masao Kaneki , Emi Nishimura
DOI: 10.1016/J.BBRC.2018.05.071
关键词:
摘要: Abstract Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes still remains unclear. We focused on inflammatory response caused by or obesity, given inflammation a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) known to be upregulated under conditions of acute chronic inflammation. To clarify potential role iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). observed ob/ob; mice were potentiated transition from telogen (rest phase) anagen (growth cycle compared iNOS-proficient ob/ob mice. determine effect (NO) cycle, administered an inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) topically (10% aminoguanidine) inhibitors promoted Next, NO donor (S-nitrosoglutathione, GSNO), test whether has elongation effects. The was sufficient induce wild-type Together, our data indicate iNOS-derived plays
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