Physiological and Pharmacological Determinants of Sensitivity and Resistance to 5-Fluorouracil in Lower Animals and Man

摘要: Publisher Summary The biological activation of 5-fluorouracil (5-FU) is dependent on the operation several enzymes. These can be aggregated into three principal groups: those that anabolize drug, catabolize it, or its anabolites, and “target” enzymes whose function finally interrupted following treatment. families are susceptible to two general types regulation: physiologic control used encompass genetic biochemical modulation pharmacologic designate synergistic antagonistic actions one drug activity other. As 5-FU continues in palliation breast gastrointestinal malignancies, more information being gathered these classes enzymes, as well manner which they regulated. This chapter discusses selected aspects such regulation, with emphasis both published original findings field. Whenever possible, absolute specific activities involved presented order reasonable intercomparisons made their relative contributions metabolism 5-FU.