摘要: Acivicin is an L-glutamine antagonist which underwent phase II clinical efficacy evaluation as anticancer drug in 1985–1986. The biochemical pharmacology of this agent unique among antimetabolites and offers several interesting possibilities for combination therapy with agents whose activity can be potentiated by acivicin, interfere cellular resistance to lessen the dose-limiting toxicity acivicin. This review will cover some experimental background current research involving relate findings preclinical drug, suggest new directions both research.
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