Phenytoin inhibits isolation-induced aggression specifically in rats with low serotonin.
作者： N. Bradley Keele
DOI: 10.1097/00001756-200105080-00012
关键词:
摘要: Phenytoin is a widely used anticonvulsant drug that also reduces aggressive behavior. Aggression in humans and animals often associated with low serotonin levels. This study examined the anti-aggressive properties of phenytoin rodent isolation-induced aggression using resident-intruder test to quantify aggression. Chronic treatment p-chlorophenyl-alanine (PCPA), competitive inhibitor synthesis, significantly enhanced resident attack behavior compared saline-treated control rats. dose-dependently reduced specifically PCPA-treated rats, but had no These data suggest this model may be related neuronal hyperexcitability sensitive effects phenytoin. Further, these rats useful investigate brain.
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