Depletion of serotonin in the basolateral amygdala elevates glutamate receptors and facilitates fear-potentiated startle
作者： L Tran , B K Lasher , K A Young , N B Keele
DOI: 10.1038/TP.2013.66
关键词: Glutamatergic 、 Serotonin 、 Glutamate receptor 、 Amygdala 、 Fear-potentiated startle 、 Neuroscience 、 Psychopharmacology 、 Endocrinology 、 Basolateral amygdala 、 Serotonergic 、 Internal medicine 、 Chemistry
摘要: Our previous experiments demonstrated that systemic depletion of serotonin (5-hydroxytryptamine, 5-HT), similar to levels reported in patients with emotional disorders, enhanced glutamateric activity the lateral nucleus amygdala (LA) and potentiated fear behaviors. However, effects isolated 5-HT LA, molecular mechanisms underlying glutamatergic are unknown. In present study, we tested hypothesis LA induces increased behavior, concomitantly enhances glutamate receptor (GluR) expression. Bilateral infusions 5,7-dihydroxytryptamine (4 μg per side) into produced a regional reduction serotonergic fibers, resulting decreased concentrations. The induction low elevated fear-potentiated startle, parallel increase GluR1 mRNA protein These findings suggest concentrations may facilitate behavior through GluR-mediated mechanisms. Moreover, our data support relationship between psychopathologies.
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