Decline in salivary S. mutans levels in children who have received short-term antibiotic therapy.

摘要: It is now well established that Streptococcus mutans (mutans streptococci) plays a central role in the initiation and progression of dental caries (Loesche 1986a). 1946 McClure Hewitt showed first evidence experimentally induced rat could be inhibited by administration penicillin to drinking water or diet. In vitro studies have shown S. susceptible penicillin, ampicillin, erythromycin, cepatholin, methicillin (Ferretti Ward 1976; Weld Sandham 1976), long term antibiotic therapy indicates this microorganism does not become resistant (Baker Thornberry 1974; 1974). Children receiving antibiotics for treatment chronic respiratory disease, rheumatic fever, immune deficiencies show shift oral flora from predominantly gram positive negative microorganisms. Additionally, these children reportedly 30-70% fewer carious lesions than nontreated cohorts (Littleton White 1964; Handelman et al. 1966; Robertson 1978). A similar reduction has been reported those individuals exposed sporadically short therapy. with history either single episodic short-term exposure tetracycline which resulted tooth discoloration significantly lower score comparison control dentitions (Brearly Porteous 1973). association between decreased scores increased use 495 ages 6 7 orally alo 1982). However, only (less 21 day) suppression was noted adults 10 days (Maltz Zickert Thus considered as contributing factor reducing caries; however, extensive data correlating decline cariogenic microorganisms Iacking contradictory. The purpose present study further examine whether often prescribed common acute infections affects level salivary over three month period.