The association of abnormal α-fetoprotein and adverse pregnancy outcome: Does increased fetal surveillance affect pregnancy outcome?

摘要: Abstract Objective: Our purpose was to investigate whether adverse outcomes associated with elevated maternal serum α-fetoprotein levels may be prevented by intensive antenatal monitoring. Study Design: Records of patients values ≥2.0 multiples the median between 1995 and 1999 were reviewed. Pregnancy histories analyzed determine monitoring (twice-weekly nonstress tests determinations amniotic fluid index) would have detected when routine obstetric care missed them. Women elevations explained multiple gestations, structural abnormalities, or a fetal death excluded. Results: The study enrolled 136 patients. Twenty-three excluded because chromosomal for lack available follow-up. Seventy-eight had no perinatal complications, but 12 these underwent heightened surveillance. One subjected an induction labor. Thirty-five pregnancies complications (21 preterm labor, 7 pregnancy-induced hypertension, 6 growth restriction oligohydramnios, 1 abruptio placentae, vasa previa). Of 35 pregnancies, 22 followed up 13 Heightened surveillance did not achieve earlier improved detection in this group. These results suggest that pregnancy management is adequate strategy providing pregnant unexplained levels. Adverse undetectable even management. Conclusion: Increased risks delivery, intrauterine restriction, death, placentae are However, our study, acceptable method detecting they detectable. (Am J Obstet Gynecol 2001;184:1549-55.)