Second-trimester maternal serum marker screening: Maternal serum α-fetoprotein, β-human chorionic gonadotropin, estriol, and their various combinations as predictors of pregnancy outcome

摘要: Objective: We evaluated the value of all 3 common biochemical serum markers, maternal α-fetoprotein, β-human chorionic gonadotropin, and unconjugated estriol, combinations thereof as predictors pregnancy outcome. Study Design: A total 60,040 patients underwent screening. All had α-fetoprotein measurements; gonadotropin was measured in 45,565 patients, 24,504 determination including estriol. The incidences various outcomes were according to marker levels by using clinically applied cutoff points. Results: In confirmation previous observations, increased (>2.5 multiples median) found be significantly associated with pregnancy-induced hypertension, miscarriage, preterm delivery, intrauterine growth restriction, fetal death, oligohydramnios, abruptio placentae. Increased median [MoM]) death. Finally, decreased estriol (<0.5 MoM) As second-trimester levels, low are adverse outcomes. These most likely attributed placental dysfunction. Conclusion: Multiple-marker screening can used not only for detection anomalies aneu-ploidy but also high-risk pregnancies. (Am J Obstet Gynecol 1999;181:968-74.)