Suppression of urokinase-type plasminogen activator mRNA levels in human fibrosarcoma cells and synovial fibroblasts by anti-inflammatory glucocorticoids.

摘要: Suppression of plasminogen activator (PA) activity has been invoked as being part the general anti-inflammatory action glucocorticoids. Low concentrations synthetic glucocorticoid, dexamethasone (Dex), reduce urokinase-type PA mRNA levels in two cell types, namely a human fibrosarcoma line, HT1080, and synovial fibroblast-like cells isolated from joints. Conversely, metallothionein IIa (MTIIa) these are raised by Dex. These findings, suggesting that it is possible to suppress at level gene expression, may have therapeutic implications for diseases such rheumatoid arthritis where proteases be contributing extensive tissue damage inflammation.