A randomized, double-blind, placebo-controlled comparison of the impact of low-dose and triphasic oral contraceptives on follicular development.
作者： Ronald L. Young , Michael C. Snabes , Margaret L. Frank , Maryanne Reilly
DOI: 10.1016/S0002-9378(11)91570-1
关键词:
摘要: OBJECTIVE: This investigation tests the hypothesis that triphasic oral contraceptives are associated with development of large, persistent ovarian cysts. STUDY DESIGN: Weekly vaginal ultrasonography was used in a randomized, double-blind, placebo-controlled, parallel-group, single-center study compared incidence, risk, size, and time to resolution follicles healthy women who took Estrostep or Loestrin (manufactured by Parke-Davis) placebo during three consecutive menstrual cycles. RESULTS: Sixty-three percent placebo-treated subjects developed >18 mm, 39% 23% groups. The risks for each group developing large follicle single cycle were not different. No dominant persisted >2 weeks any subject. CONCLUSION: These results demonstrate follicular continues treatment contraceptives. In addition, findings fail support result
sci-hub.se 参考文章(10)
Stephen Killick, Effi Eyong, Max Elstein, Ovarian follicular development in oral contraceptive cycles. Fertility and Sterility. ,vol. 48, pp. 409- 413 ,(1987) , 10.1016/S0015-0282(16)59407-2
D Shoupe, J Horenstein, DR Mishell, M Lacarra, A Medearis, Characteristics of ovarian follicular development in Norplant users. Fertility and Sterility. ,vol. 55, pp. 236- 236 ,(1992) , 10.1016/0020-7292(92)90412-C
Donna Shoupe, Janet Horenstein, Daniel R. Mishell, Maria Lacarra, Arnold Medearis, Characteristics of ovarian follicular development in Norplant* users†*Norplant, supplied by Population Council, New York, New York; manufactured by Leiras, Turku, Finland.†This work was undertaken as a part of the contraceptive development program sponsored and coordinated by the International Committee for Contraception Research of the Population Council Inc, New York, New York. Fertility and Sterility. ,vol. 55, pp. 766- 770 ,(1991) , 10.1016/S0015-0282(16)54245-9
S R Schwimer, J Lebovic, Transvaginal pelvic ultrasonography: accuracy in follicle and cyst size determination. Journal of Ultrasound in Medicine. ,vol. 4, pp. 61- 63 ,(1985) , 10.7863/JUM.1985.4.2.61
David E. Lilienfeld, Abraham M. Lilienfeld, Foundations of Epidemiology ,(1980)
James C. Caillouette, Arthur L. Koehler, Phasic contraceptive pills and functional ovarian cysts. American Journal of Obstetrics and Gynecology. ,vol. 156, pp. 1538- 1542 ,(1987) , 10.1016/0002-9378(87)90028-7
Ultrasound demonstration of increased frequency of functional ovarian cysts in women using progestogen‐only oral contraception British Journal of Obstetrics and Gynaecology. ,vol. 92, pp. 1003- 1009 ,(1985) , 10.1111/J.1471-0528.1985.TB02994.X
By J. B. S. HALDANE, The estimation and significance of the logarithm of a ratio of frequencies. Annals of Human Genetics. ,vol. 20, pp. 309- 311 ,(1956) , 10.1111/J.1469-1809.1955.TB01285.X
John T. Queenan, Gregory D. O’brien, Lyn M. Bains, Janet Simpson, William P. Collins, Stuart Campbell, Ultrasound scanning of ovaries to detect ovulation in women. Fertility and Sterility. ,vol. 34, pp. 99- 105 ,(1980) , 10.1016/S0015-0282(16)44889-2
David A. Grimes, Joyce M. Hughes, Use of multiphasic oral contraceptives and hospitalizations of women with functional ovarian cysts in the United States. Obstetrics & Gynecology. ,vol. 73, pp. 1037- 1039 ,(1989) , 10.1097/00006250-198906000-00026