Microglia: new roles for the synaptic stripper

摘要: Any pathologic event in the brain leads to activation of microglia, immunocompetent cells central nervous system. In recent decades diverse molecular pathways have been identified by which microglial is controlled and activated microglia affects neurons. normal were considered "resting," but it has recently become evident that they constantly scan environment contact synapses. Activated can remove damaged as well dysfunctional synapses, a process termed "synaptic stripping." Here we summarize evidence characterized pathology are also utilized developing influence synaptic development connectivity, therefore should targets future research. Microglial dysfunction results behavioral deficits, indicating essential for proper function. This defines new role beyond being mere sensor.