Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia
作者： Amany K Elshorbagy , Maria Valdivia-Garcia , Helga Refsum , A David Smith , Dwight AL Mattocks
DOI: 10.1016/J.NUT.2009.09.017
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摘要: Abstract Objective Dietary methionine restriction in Fischer-344 rats favorably influences visceral fat mass, insulin sensitivity, metabolic parameters, and longevity. However, little is known about the effects of on serum its downstream sulfur amino acids. We investigated acid profile male fed a methionine-restricted diet for 3 mo. Methods results Using tandem mass spectrometry, we observed marked reduction concentrations methionine, cystathionine, cysteine, taurine compared with control ( P Conclusion This suggests that homocysteine trans-sulfuration may be inhibited by restriction, some mediated changes acids methionine.
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