Resveratrol Ameliorates Pressure Overload–induced Cardiac Dysfunction and Attenuates Autophagy in Rats

摘要: Pressure overload has an important role in heart failure, inducing excessive autophagy cardiac myocytes that is considered to be pathogenic. Resveratrol been reported improve dysfunction induced by pressure overload, but it unclear whether resveratrol ameliorates regulating autophagy. In this study, failure was rats constriction of the abdominal aorta. Four weeks after surgery, with were randomized treatment (8 mg · kg(-1) d(-1) intraperitoneal injection) for 28 days or injection vehicle (propylene glycol) alone. Echocardiography performed assess function. Expression brain natriuretic peptide messenger RNA left ventricle detected real-time polymerase chain reaction, whereas expression proteins associated (beclin-1 and lamp-1) western blotting immunohistochemistry. Furthermore, autophagic vacuoles transmission electron microscopy, myocardial ATP content measured bioluminescence method. Treatment significantly improved reduced failure. down-regulated beclin-1 lamp-1 also inhibited formation failing hearts. restored level phosphorylation AMP-activated protein kinase at Thr172. These results suggest may inhibit through inactivation restoration overload. Accordingly, beneficial patients hypertensive disease.