MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia
作者： Karin Vargova , Nikola Curik , Pavel Burda , Petra Basova , Vojtech Kulvait
DOI: 10.1182/BLOOD-2010-05-285064
关键词:
摘要: Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed subset B-CLL patients. physically associates with the promoter host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides hypermethylated histone H3K4 residue spread hyperacetylation H3K9 at MIR155HG promoter. Our data provide oncogenic activities include stimulatory role
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bloodjournal.org参考文章(53)
Victor Ambros, microRNAs: Tiny Regulators with Great Potential Cell. ,vol. 107, pp. 823- 826 ,(2001) , 10.1016/S0092-8674(01)00616-X
A.I. Saeed, V. Sharov, J. White, J. Li, W. Liang, N. Bhagabati, J. Braisted, M. Klapa, T. Currier, M. Thiagarajan, A. Sturn, M. Snuffin, A. Rezantsev, D. Popov, A. Ryltsov, E. Kostukovich, I. Borisovsky, Z. Liu, A. Vinsavich, V. Trush, J. Quackenbush, TM4: a free, open-source system for microarray data management and analysis. BioTechniques. ,vol. 34, pp. 374- 378 ,(2003) , 10.2144/03342MT01
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
KR Rai, A Sawitsky, EP Cronkite, AD Chanana, RN Levy, BS Pasternack, Clinical staging of chronic lymphocytic leukemia. Blood. ,vol. 46, pp. 219- 234 ,(1975) , 10.1182/BLOOD.V46.2.219.219
Teresa Bellon, Danilo Perrotti, Bruno Calabretta, Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter Blood. ,vol. 90, pp. 1828- 1839 ,(1997) , 10.1182/BLOOD.V90.5.1828
S. R. McKercher, B. E. Torbett, K. L. Anderson, G. W. Henkel, D. J. Vestal, H. Baribault, M. Klemsz, A. J. Feeney, G. E. Wu, C. J. Paige, R. A. Maki, Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. The EMBO Journal. ,vol. 15, pp. 5647- 5658 ,(1996) , 10.1002/J.1460-2075.1996.TB00949.X
Alexander I. Saeed, Nirmal K. Bhagabati, John C. Braisted, Wei Liang, Vasily Sharov, Eleanor A. Howe, Jianwei Li, Mathangi Thiagarajan, Joseph A. White, John Quackenbush, TM4 microarray software suite Methods in Enzymology. ,vol. 411, pp. 134- 193 ,(2006) , 10.1016/S0076-6879(06)11009-5
J. L. Binet, A. Auquier, G. Dighiero, C. Chastang, H. Piguet, J. Goasguen, G. Vaugier, G. Potron, P. Colona, F. Oberling, M. Thomas, G. Tchernia, C. Jacquillat, P. Boivin, C. Lesty, M. T. Duault, M. Monconduit, S. Belabbes, F. Gremy, A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis Cancer. ,vol. 48, pp. 198- 206 ,(1981) , 10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V
Elena Vigorito, Kerry L. Perks, Cei Abreu-Goodger, Sam Bunting, Zou Xiang, Susan Kohlhaas, Partha P. Das, Eric A. Miska, Antony Rodriguez, Allan Bradley, Kenneth G.C. Smith, Cristina Rada, Anton J. Enright, Kai-Michael Toellner, Ian C.M. MacLennan, Martin Turner, microRNA-155 Regulates the Generation of Immunoglobulin Class-Switched Plasma Cells Immunity. ,vol. 27, pp. 847- 859 ,(2007) , 10.1016/J.IMMUNI.2007.10.009
P. S. Eis, W. Tam, L. Sun, A. Chadburn, Z. Li, M. F. Gomez, E. Lund, J. E. Dahlberg, Accumulation of miR-155 and BIC RNA in human B cell lymphomas Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 3627- 3632 ,(2005) , 10.1073/PNAS.0500613102