Epigenetic responses and the developmental origins of health and disease.

摘要: Maternal and paternal factors influence offspring development program its genome for successful postnatal life. Based on the stressors during gestation, pregnant female prepares fetus outside environment. This preparation is achieved by changing epigenome of referred to as 'developmental programming'. For instance, nutritional insufficiency in utero will lead programming events that prepare cope up with nutrient scarcity following birth; however, may not face birth. discrepancy between predicted exposed environments are perceived 'stress' result cardiovascular metabolic disorders. Thus, this developmental be both beneficial well harmful depending prenatal vs Over past three decades, accumulating evidence supports hypothesis Developmental Origin Health Disease (DOHaD) fetal phenotype without altering genotype per se. These heritable modifications gene expression occur through DNA methylation, histone modification noncoding RNA-associated activation or silencing, all defined epigenetic modifications. In present review, we summarize supporting regulation a significant component DOHaD.