Insights into the mechanism for dictating polarity in migrating T-cells.

摘要: Abstract This review is focused on mechanisms of chemokine-induced polarization T-lymphocytes. Polarization involves, starting from spherical cells, formation a morphologically and functionally different rear (uropod) front (leading edge). required for efficient random directed T-cell migration. The addressed topics concern the specific location cell organelles receptors, signaling molecules, cytoskeletal proteins in chemokine-stimulated polarized T-cells. In chemokine-stimulated, T-cells, proteins, molecules show enrichment either rear, midzone, or front; resting cells. Possible involved this asymmetric will be discussed. A major topic also functional role Specifically, roles adhesion chemokine scaffolding membrane microdomains these processes polarity which established during contact T-cells with antigen-presenting cells not discussed detail.