Effect of androgens on the cranial suspensory ligament and ovarian position.

摘要: Androgens have been postulated to a major role in testicular descent via regression of the cranial suspensory ligament, which normal rodents anchors ovary retroperitoneum near lower pole kidney. This study aimed quantitate degree foetal androgen-treated female mice determine androgens ligament and testis. Time-pregnant were injected with testosterone propionate or methyl (2.5–3.0 mg) vehicle on day 13 14. Control animals received only. Newborn anaesthetised dissected for macroscopic anatomy ovary, was quantified by measuring vertical distance from kidney ovary. Histological analysis also performed. The external genitalia masculinised all females exposed prenatal androgens. ovaries treated mobile, no located slightly caudal Wolffian duct structures identifiable, but gubernaculum qualitatively unchanged compared control females. displaced caudally (P< 0.001), only 15–25% abdomen. Exogenous induce causing be more mobile abdominal cavity. However, since position at birth is below bladder neck, androgen-mediated an adjunct transabdominal descent. Anat Rec 255:306–315, 1999. © 1999 Wiley-Liss, Inc.