Mesenchymal Stem Cells and Umbilical Cord as Sources for Schwann CellDifferentiation: their Potential in Peripheral Nerve Repair

摘要: Schwann cells are important components of the peripheral glia that form myelin, serving as microenvironment nerve fibers in nervous system (PNS). Damage to PNS induces differentiation and activation produce factors strongly promote axonal regrowth, subsequently contribute remyelination, which is crucial for recovery function. Although collection transplantation native effective treatment neural diseases, isolation results new damage other segments causes undesirable iatrogenic injury donor. Furthermore, expansion obtain a sufficient number clinical application within reasonable period technically difficult. Therefore, method induce easily accessible highly proliferative differentiate into with cell properties would be very practical desirable. Recently, regenerative medicine has focused on mesenchymal stem because they from various kinds tissues such umbilical cord, bone marrow, fat tissue. Mesenchymal it easy an adequate cells. Notably, while mesodermal lineage cells, have ability cross oligolineage boundaries previously thought uncrossable achieve transdifferentiation. In this review, we focus potential particularly cord-derived functional discuss prospective these regeneration.