Batch Injection Analysis Utilizing Modified Electrodes with Tetraruthenated Porphyrin Films for Acetaminophen Quantification

摘要: Batch injection analysis (BIA) utilizing amperometric detection with glassy carbon electrodes modified [Co(TPyP){Ru(bipy)2Cl}4](TFMS)5⋅H2O porphyrin films were explored for acetaminophen in pharmaceutical formulations. BIA is an interesting alternative application of tetraruthenated porphyrins. This sensor exhibited sharp current response peaks, rapid washout and excellent reproducibility BIA-amperometric quantification acetaminophen. Also, a wide linear working range (10−4 to 10−6 mol L−1) as well high sensitivity sampling frequency rate (detection limit=1.1×10−7 mol L−1, frequency=120 injections/h) small volume (100 μL/injection) was achieved. Furthermore, the proposed method permits direct many products, avoiding cumbersome processes previous separations, solvent extraction or sample filtration. The new procedure applied commercial products results agreement ones obtained by spectrophotometric method. Accordingly, this showed be very suited quality control other applications similar requirements.