Synthesis and Photophysical Characterisation of Fluorescent 8-(1H-1,2,3-Triazol-4-yl)adenosine Derivatives

摘要: A series of 8-(1H-1,2,3-triazol-4-yl)-substituted adenosine derivatives have been synthesised by using Sonogashira cross-coupling and click chemistry. The use chemistry enables an easy access to different substituents in the 4-position triazole ring. modified nucleosides show high absorptivities due a single strongly allowed electronic transition and, for some derivatives, quantum yields organic as well water solution making them promising fluorescent probes nucleic acid contexts. Furthermore, 1,2,3-triazole makes wavelength emission tunable without changing absorption properties substantially. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)