Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer’s Disease

摘要: The world's population continues to age at a rapid pace. By the year 2050, individuals over of 65 will account for sixteen percent and life expectancy increase well eighty years age. Accompanied by aging global is significant rise in Non-Communicable Diseases (NCDs). Neurodegenerative disorders form component NCDs. Currently, dementia 7th leading cause death can be result multiple causes that include diabetes mellitus, vascular disease, Alzheimer's Disease (AD). AD may represent least sixty these cases. Current treatment extremely limited provide only some symptomatic relief present. Sirtuins particular, silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), innovative strategies cognitive loss. New work has revealed SIRT1 provides protection against memory loss through mechanisms involve oxidative stress, Aβ toxicity, neurofibrillary degeneration, injury, mitochondrial dysfunction, neuronal In addition, relies upon other avenues trophic factors, such as erythropoietin, signaling pathways, Wnt1 inducible pathway protein (WISP1/CCN4). Yet, have detrimental effects tumorigenesis blockade stem cell differentiation maturation limit reparative processes Further investigations with sirtuins should able capitalize novel targets