Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-γ production: benefits of omega-3 with curcumin against cancer

摘要: STAT-3 and STAT-1 signaling have opposite effects in oncogenesis with acting as an oncogene exerting anti-oncogenic activities through interferon-γ interferon-α. The cytokine IL-6 promotes by stimulation of NFκB signaling. Curcuminoids bi-functional blocking anti-apoptotic but also production. In our recent study (unpublished work [1]) pancreatic cancer cell cultures, curcuminoids enhanced apoptosis both directly potentiating natural killer (NK) cytotoxic function. were increased incubation cells NK emulsion omega-3 fatty acids antioxidants (Smartfish), which protected against degradation. However, shown others, blocked production cells. combined use immunotherapy will require deeper understanding their vivo interactions the immune system.