sKlotho is associated with the severity of brick tea-type skeletal fluorosis in China.
作者： Yang Liu , Yanmei Yang , Yudan Wei , Xiaona Liu , Bingyun Li
DOI: 10.1016/J.SCITOTENV.2020.140749
关键词:
摘要: Abstract The change of serum soluble Klotho (sKlotho) content is related to a variety osteoarthropathy. However, its association with the severity skeletal fluorosis (SF) not clear. Here, tea fluoride exposure sKlotho levels and SF were investigated further verified in rat model fluorosis. A cross sectional case control study was conducted residents over 50 years old from brick-tea drinking areas Qinghai Xinjiang Provinces, China. Concentrations brick water urine determined by ion selective electrode method, ELISA method. Linear regression ordered logistic models constructed examine relationship among exposure, SF. kidney small intestine Wistar rats isolated for detection immunohistochemistry (IHC), femoral artery blood sampled measure sKlotho. An increase 1 mg/day intake (TFI) associated 12.070 pg/mL (95% CI: 0.452–23.689) 1.163-fold 1.007–1.342) after adjusting age, gender, ethnicity. Serum also positively (P
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