摘要: In this review, the current state of vaccine development against human severe acute respiratory syndrome (SARS) coronavirus, focusing on recently published data is assessed. We discuss which strategies have been assessed immunologically and evaluated in SARS coronavirus challenge models. inactivated vaccines, virally bacterially vectored recombinant protein DNA as well use attenuated vaccines. Data regarding correlates protection, animal models available evidence potential enhancement disease are discussed. While there much that various safe immunogenic, vaccinated animals still display significant upon challenge. Current suggest intranasal vaccination may be crucial new or combination required for good protective efficacy humans.
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