Immunization against neonatal tetanus in New Guinea. 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response.

摘要: Previous papers in this series have shown that plain toxoids induced early primary antitoxin levels women New Guinea were not significantly different from those by adsorbed but at the end of 1 year differed significantly. Protective (not less than 0.01 unit/ml) persisted for more 3 years. Results laboratory assays reported paper show per total human immunizing dose, had 72 or international units (IU) whereas approximately 200 IU. The "unitage" these reflected persistence protective level response. assay results agreement with findings other workers mouse as well guinea-pig may be satisfactory potency toxoids. need determination unitage tetanus used studies and confirmation relationship value to is emphasized.