摘要: Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that involved in the folding, activation, and stabilization of numerous oncogenic proteins. It has become attractive therapeutic target, especially for eradicating malignant cancers overcoming chemotherapy resistance. The Hsp90 family mammalian cells composed four major homologs: Hsp90α, Hsp90β, 94-kDa glucose-regulated (Grp94), TNF receptor-associated 1 (Trap1). Hsp90α Hsp90β are mainly localized cytoplasm, while Grp94 Trap1 reside endoplasmic reticulum mitochondria, respectively. Additionally, some Hsp90 s secreted from commonly called extracellular Hsp90. Interestingly, each isoform a particular organelle, possesses unique biological function, participates various physiological pathological processes. To inhibit organelle-specific there have been significant efforts to accumulate inhibitors cellular compartments. This review introduces current studies regarding delivery subcellular organelles, particularly matrix discusses their insights implications.
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