Targeting HSP90 for cancer therapy

摘要: Heat-shock proteins (HSPs) are molecular chaperones that regulate protein folding to ensure correct conformation and translocation avoid aggregation. increased in many solid tumours haematological malignancies. Many oncogenic responsible for the transformation of cells cancerous forms client HSP90. Targeting HSP90 with chemical inhibitors would degrade these proteins, thus serve as useful anticancer agents. This review provides an overview HSP chaperone machinery structure function We also highlight key regulated by describe how inhibition could alter activity multiple signalling receptors transcriptional factors implicated carcinogenesis.