摘要: The increase in body size of humans and other vertebrates requires a physiological infrastructure to provide adequate delivery oxygen tissues cells maintain homeostasis. heart, lungs the vasculature are all part highly regulated system that ensures distribution precise amount needed throughout mammalian organism. Given its fundamental impact on physiology pathology, it is no surprise response lack oxygen, termed hypoxia, has been focus many research groups worldwide for decades now. transcriptional complex hypoxia-inducible factor emerged as key regulator molecular hypoxic response, mediating wide range cellular mechanisms necessary adapt reduced oxygen.
nature.com
sci-hub.se 参考文章(77)
Georg Oberhuber, Peter Birner, Gerhard Breitenecker, Monika Schindl, Andreas Obermair, Christina Plank, Overexpression of Hypoxia-inducible Factor 1α Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer Cancer Research. ,vol. 60, pp. 4693- 4696 ,(2000)
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
Won G. An, Meera Kanekal, M. Celeste Simon, Emin Maltepe, Mikhail V. Blagosklonny, Leonard M. Neckers, Stabilization of wild-type p53 by hypoxia-inducible factor 1α Nature. ,vol. 392, pp. 405- 408 ,(1998) , 10.1038/32925
D. E. Richard, Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells Journal of Biological Chemistry. ,vol. 275, pp. 26765- 26771 ,(2000) , 10.1074/JBC.M003325200
Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. ,vol. 399, pp. 271- 275 ,(1999) , 10.1038/20459
Jeffrey M. Arbeit, David A. Elson, Randall Johnson, Jonathan W. Snow, Heather E. Ryan, Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Research. ,vol. 60, pp. 6189- 6195 ,(2000)
Carole Peyssonnaux, Pilar Cejudo-Martin, Andrew Doedens, Annelies S. Zinkernagel, Randall S. Johnson, Victor Nizet, Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. Journal of Immunology. ,vol. 178, pp. 7516- 7519 ,(2007) , 10.4049/JIMMUNOL.178.12.7516
B. H. Jiang, G. L. Semenza, C. Bauer, H. H. Marti, Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. American Journal of Physiology-cell Physiology. ,vol. 271, ,(1996) , 10.1152/AJPCELL.1996.271.4.C1172
Christopher W. Pugh, John F. O'Rourke, Masaya Nagao, Jonathan M. Gleadle, Peter J. Ratcliffe, Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit Journal of Biological Chemistry. ,vol. 272, pp. 11205- 11214 ,(1997) , 10.1074/JBC.272.17.11205
David Lando, Daniel J Peet, Dean A Whelan, Jeffrey J Gorman, Murray L Whitelaw, Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science. ,vol. 295, pp. 858- 861 ,(2002) , 10.1126/SCIENCE.1068592