Altered cognition-related brain activity and interactions with acute pain in migraine

摘要: Little is known about the effect of migraine on neural cognitive networks. However, dysfunction increasingly being recognized as a comorbidity chronic pain. Pain appears to affect ability and function networks over time, decrements in can exacerbate affective sensory components We investigated differences processing pain–cognition interactions between 14 patients matched healthy controls using an fMRI block-design with two levels task difficulty concurrent heat (painful not painful) stimuli. Across groups, were recruited response difficult task, pain–task interaction was found right (contralateral pain stimulus) posterior insula (pINS), such that activity modulated by decreasing thermal stimulus or engaging task. Migraine had less task-related deactivation within left dorsolateral prefrontal cortex (DLPFC) dorsal anterior midcingulate (aMCC) compared controls. These regions have been reported decreased cortical thickness cognitive-related other populations, are also associated regulation, suggesting current findings may reflect altered top-down regulation During conditions, activity, but more widespread reductions pain-related controls, resources be diverted from pain-reduction-related processes migraine. Overall, these suggest which regulatory well broader functional restructuring.