Effect of matrine on HeLa cell adhesion and migration
作者： Lijun Zhang , Tingting Wang , Xianmei Wen , Yun Wei , Xiaochun Peng
DOI: 10.1016/J.EJPHAR.2007.01.073
关键词:
摘要: Abstract This study sought to explore the role of matrine in metastasis cancer cells and gain insight into possible mechanism matrine's ability inhibit metastasis. Accordingly, changes vasodilator-stimulated phosphoprotein (VASP) phosphorylation cAMP-dependent protein kinase (PKA) activity during cell detachment reattachment were first investigated. After administration (50 μg/ml), decrease VASP paralleled PKA activity. Matrine was found significantly HeLa adhesion collagen I. To determine effect on migration cells, we analysed migratory behaviour a two three-dimensional assay. In two-dimensional assay, average velocity reduced by compared with control. Moreover, assay performed Transwell system, treated (50 μg/ml) migrate less than control cells. These data suggest that inhibitory may be produced decreased due inhibition migration.
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