Chromosome Aberrations Induced in Human Lymphocytes by 16·5 MeV Protons

摘要: SummaryIn a track segment irradiation experiment with 16·5 MeV protons the induction of dicentrics was studied in human T-lymphocytes. The dose—response relationship linear quadratic estimated parameters α = (0·44 ± 0·07) × 10−1 Gy−1 and β (1·95 0·30) 10−2 Gy−2. With respect to X-rays limiting RBE 1·1–1·2 exists. present findings are compared data from other laboratories obtained 4·9 8·7 protons. It found that do not fit theoretical predictions on proportional between values LET. Using microdosimetric quantity y¯D (25 nm), dose average lineal energy, for characterization these proton radiations, at relevant site diameter 25 nm ratio 1·15 is accordance only observed 1·0 0·23 In contrast prediction constant low LET values, coefficients increase increasing 3 8 keV/μm.