CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells
作者： Zhifeng Miao , Zhenning Wang , Yingying Xu , Jianhua Wu , Xingyu Liu
DOI: 10.1007/S13277-013-0869-X
关键词:
摘要: CARMA3 was recently reported to be overexpressed in several cancers and associated with malignant behavior of cancer cells. However, the expression pattern biological roles breast have not been reported. In present study, we found that 41.9 % specimens. Significant association observed between overexpression TNM stage (p = 0.0223), tumor size 0.0227), ErbB-2 status 0.0049). Furthermore, knockdown MDA-MB-435 cells high endogenous decreased cell proliferation sensitized paclitaxel-induced apoptosis, while MDA-MB-231 line promoted inhibited apoptosis. Further analysis showed depletion downregulated, its upregulated cyclin D1, Bcl-2, p-IκB levels. conclusion, our study demonstrated is cancers. facilitates inhibits apoptosis through nuclear factor-kappaB signaling.
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sci-hub.se 参考文章(24)
S Umar, S Sarkar, S Cowey, P Singh, Activation of NF-κB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo Oncogene. ,vol. 27, pp. 5599- 5611 ,(2008) , 10.1038/ONC.2008.169
Rafael Molina, Jose M. Augé, Jose M. Escudero, Xavier Filella, Gabriel Zanon, Jaume Pahisa, Blanca Farrus, Montserrat Muñoz, Martin Velasco, Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: prognostic value Tumor Biology. ,vol. 31, pp. 171- 180 ,(2010) , 10.1007/S13277-010-0025-9
K E Knudsen, J Alan Diehl, C A Haiman, E S Knudsen, Cyclin D1: polymorphism, aberrant splicing and cancer risk Oncogene. ,vol. 25, pp. 1620- 1628 ,(2006) , 10.1038/SJ.ONC.1209371
Jiyuan Sun, CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases World Journal of Biological Chemistry. ,vol. 1, pp. 353- 361 ,(2010) , 10.4331/WJBC.V1.I12.353
Weiming Ouyang, Qian Ma, Jingxia Li, Dongyun Zhang, Zheng-gang Liu, Anil K. Rustgi, Chuanshu Huang, Cyclin D1 Induction through IκB Kinase β/Nuclear Factor-κB Pathway Is Responsible for Arsenite-Induced Increased Cell Cycle G1-S Phase Transition in Human Keratinocytes Cancer Research. ,vol. 65, pp. 9287- 9293 ,(2005) , 10.1158/0008-5472.CAN-05-0469
Linda M. McAllister-Lucas, Naohiro Inohara, Peter C. Lucas, Jürgen Ruland, Adalberto Benito, Qiutang Li, Shu Chen, Felicia F. Chen, Shoji Yamaoka, Inder M. Verma, Tak W. Mak, Gabriel Núñez, Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction Journal of Biological Chemistry. ,vol. 276, pp. 30589- 30597 ,(2001) , 10.1074/JBC.M103824200
Qing Xia, Zhihua Zhu, Jian Wang, Dongrong Situ, Ningning Zhou, Wenqi Jang, Expression and association of HER2 with prognosis in early-stage (T1–T2N0M0) non-small cell lung cancer Tumor Biology. ,vol. 33, pp. 1719- 1725 ,(2012) , 10.1007/S13277-012-0429-9
Dimitrios Korbakis, Andreas Scorilas, Quantitative expression analysis of the apoptosis-related genes BCL2 , BAX and BCL2L12 in gastric adenocarcinoma cells following treatment with the anticancer drugs cisplatin, etoposide and taxol Tumor Biology. ,vol. 33, pp. 865- 875 ,(2012) , 10.1007/S13277-011-0313-Z
Qing Yao, Jianghao Chen, Yonggang Lv, Ting Wang, Juliang Zhang, Jing Fan, Ling Wang, The significance of expression of autophagy-related gene Beclin, Bcl-2, and Bax in breast cancer tissues. Tumor Biology. ,vol. 32, pp. 1163- 1171 ,(2011) , 10.1007/S13277-011-0219-9
Hanna Lindberg, Camilla Hofström, Mohamed Altai, Hadis Honorvar, Helena Wållberg, Anna Orlova, Stefan Ståhl, Torbjörn Gräslund, Vladimir Tolmachev, Evaluation of a HER2-targeting affibody molecule combining an N-terminal HEHEHE-tag with a GGGC chelator for 99mTc-labelling at the C terminus Tumor Biology. ,vol. 33, pp. 641- 651 ,(2012) , 10.1007/S13277-011-0305-Z