Using a Telephone Survey to Acquire Genetic and Behavioral Data Related to Cigarette Smoking in “Made-Anonymous” and “Registry” Samples

摘要: In the Smokers and Nonsmokers Study, authors investigated feasibility of using random digit dialing telephone interviews to locate adults in continental United States who were willing provide DNA from buccal swabs through mail. Interviews with 3,383 regarding their smoking-related behaviors (response rate = 70%) conducted 1999-2000; swab returns continued into early 2001. Overall, 57% interviewees agreed receive mailed information explaining study. Better-educated persons (odds ratio (OR) 1.3, 95% confidence interval (CI): 1.1, 1.6), younger (OR 0.988, CI: 0.983, 0.992), symptoms depression 1.8, 1.4, 2.4), current smokers 2.25, 2.8) likelier agree a mailing. Approximately 26% (45% those receiving kits) returned swabs, 18% successfully genotyped. Older 1.02, 1.01, 1.03), better-educated 1.7), White 2.5) participants more likely return samples, but 0.6, 0.5, 0.8) less do so. Participants randomly assigned one two forms participation: "registry" group (names kept on file) or "made-anonymous" unassociated samples). The groups equally kits, registry respondents nominate siblings for participation study 1.6, 1.2, 2.1). this similar demographically national population. conclude that surveys coupled mail collection may constitute practical method obtaining samples biobehavioral research.