ABO Blood Groups and Risk of Cancer: a Systematic Review and Meta-analysis

摘要: Background: For decades, studies have been performed to evaluate the association between ABO blood groups and risk of cancer. However, whether are associated with overall cancer remains unclear. We therefore conducted a meta-analysis observational assess this association. Materials Methods: A search Pubmed, Embase, ScienceDirect, Wiley, Web Knowledge databases (to May 2013) was supplemented by manual searches bibliographies key retrieved articles relevant reviews. included case-control cohort more than 100 cases. Results: The yielded 89 eligible that reported 100,554 cases at 30 sites. risk, pooled OR 1.12 (95%CI: 1.09-1.16) for vs. non- groups, 0.84 0.80-0.88) O non-O groups. individual sites, group found confer increased gastric (OR=1.18; 95%CI: 1.13-1.24), pancreatic (OR=1.23; 1.15-1.32), breast (OR=1.12; 1.01-1.24), ovarian (OR=1.16; 1.04-1.27), nasopharyngeal (OR=1.17; 1.00-1.33). Blood be linked decreased (OR=0.84; 0.80-0.88), (OR=0.75; 0.70-0.80), (OR=0.90; 0.85-0.95), colorectal (OR=0.89; 0.81-0.96), (OR=0.76; 0.53-1.00), esophagus (OR=0.94; 0.89-1.00), (OR=0.81; 0.70-0.91). Conclusions: is cancer,